Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
نویسندگان
چکیده
Diterpene glucoside fusicoccin A (FC-A) is a phytotoxic fungal metabolite that stabilizes the interactions between 14-3-3 protein and phosphorylated ligand protein. 14-3-3-mediated binding central to regulation of serine/threonine kinase signaling pathway in all eukaryotic cells essential for controlling numerous biological processes. Thus, fusicoccins could serve as robust platform developing new chemical probes pharmaceuticals. This review describes recent progress toward understanding biosynthetic pathways rational design inhibitors stabilizers, well their antitumor activities. Consequently, towards fusicoccins, stabilizers
منابع مشابه
Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 2021
ISSN: ['0366-7022', '1348-0715']
DOI: https://doi.org/10.1246/cl.200670